SENP3 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human SENP3 peptide using ARM Technology.
Immunogen
A synthetic peptide of human SENP3 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human SENP3 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — SENP3
Entrez GeneID
26168GeneBank Accession#
SENP3Gene Name
SENP3
Gene Alias
DKFZp586K0919, DKFZp762A152, SMT3IP1, SSP3
Gene Description
SUMO1/sentrin/SMT3 specific peptidase 3
Gene Ontology
HyperlinkGene Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM
Other Designations
SUMO1/sentrin/SMT3 specific protease 3|sentrin/SUMO-specific protease 3
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Interactome
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Disease
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