HERC4 monoclonal antibody (M08), clone 2G7
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant HERC4.
Immunogen
HERC4 (NP_071362, 341 a.a. ~ 440 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSF
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (96)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged HERC4 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — HERC4
Entrez GeneID
26091GeneBank Accession#
NM_022079Protein Accession#
NP_071362Gene Name
HERC4
Gene Alias
DKFZp564G092, KIAA1593
Gene Description
hect domain and RLD 4
Omim ID
609248Gene Ontology
HyperlinkGene Summary
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM
Other Designations
OTTHUMP00000019692
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Interactome
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Pathway
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Disease
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