Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

CNTNAP2

Gene Alias

AUTS15, CASPR2, CDFE, DKFZp781D1846, NRXN4

Gene Description

contactin associated protein-like 2

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons and associated with potassium channels. It may play a role in the local differentiation of the axon into distinct functional subdomains. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It may represent a positional candidate gene for the DFNB13 form of nonsyndromic deafness. [provided by RefSeq

Other Designations

cell recognition molecule Caspr2|contactin-associated protein 2|homolog of Drosophila neurexin IV