CHMP2B DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human CHMP2B DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — CHMP2B
Entrez GeneID
25978GeneBank Accession#
NM_014043.2Protein Accession#
NP_054762.2Gene Name
CHMP2B
Gene Alias
CHMP2.5, DKFZp564O123, DMT1, VPS2-2, VPS2B
Gene Description
chromatin modifying protein 2B
Gene Ontology
HyperlinkGene Summary
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq
Other Designations
charged multivesicular body protein 2b|vacuolar protein-sorting-associated protein 2-2
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Interactome
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Pathway
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Disease
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