SOSTDC1 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human SOSTDC1 full-length ORF ( NP_056279.1, 1 a.a. - 206 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
49.7
Interspecies Antigen Sequence
Mouse (97); Rat (96)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SOSTDC1
Entrez GeneID
25928GeneBank Accession#
NM_015464.2Protein Accession#
NP_056279.1Gene Name
SOSTDC1
Gene Alias
CDA019, DKFZp564D206, ECTODIN, USAG1
Gene Description
sclerostin domain containing 1
Omim ID
609675Gene Ontology
HyperlinkGene Summary
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq
Other Designations
cystine-knot containing secreted protein|ectodermal BMP inhibitor|uterine sensitization-associated protein-1
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Interactome
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Publication Reference
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Shh signaling is essential for rugae morphogenesis in mice.
Lee JM, Miyazawa S, Shin JO, Kwon HJ, Kang DW, Choi BJ, Lee JH, Kondo S, Cho SW, Jung HS.
Histochemistry and Cell Biology 2011 Dec; 136(6):663.
Application:Treated, Recombinant protein.
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Shh signaling is essential for rugae morphogenesis in mice.
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