MTHFD1L monoclonal antibody (M01), clone 1E8
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MTHFD1L.
Immunogen
MTHFD1L (NP_056255, 801 a.a. ~ 899 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQG
Host
Mouse
Reactivity
Human, Rat
Interspecies Antigen Sequence
Mouse (96); Rat (96)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
MTHFD1L monoclonal antibody (M01), clone 1E8 Western Blot analysis of MTHFD1L expression in PC-12 ( Cat # L012V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged MTHFD1L is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — MTHFD1L
Entrez GeneID
25902GeneBank Accession#
NM_015440Protein Accession#
NP_056255Gene Name
MTHFD1L
Gene Alias
DKFZp586G1517, FLJ21145, FTHFSDC1, MTC1THFS, dJ292B18.2
Gene Description
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Omim ID
611427Gene Ontology
HyperlinkGene Summary
One-carbon substituted forms of tetrahydrofolate (THF) are involved in the de novo synthesis of purines and thymidylate and support cellular methylation reactions through the regeneration of methionine from homocysteine. MTHFD1L is an enzyme involved in THF synthesis in mitochondria (Christensen et al., 2005 [PubMed 15611115]).[supplied by OMIM
Other Designations
OTTHUMP00000017418|formyltetrahydrofolate synthetase domain containing 1|mitochondrial C1-tetrahydrofolate synthase|mitochondrial C1-tetrahydrofolate synthetase
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Interactome
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Pathway
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Disease
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