DFNB31 monoclonal antibody (M02), clone 1D9
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant DFNB31.
Immunogen
DFNB31 (NP_056219, 808 a.a. ~ 907 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLVTEFNVML
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (95)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged DFNB31 is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — DFNB31
Entrez GeneID
25861GeneBank Accession#
NM_015404Protein Accession#
NP_056219Gene Name
DFNB31
Gene Alias
CIP98, DKFZp434N014, KIAA1526, RP11-9M16.1, USH2D, WHRN, WI
Gene Description
deafness, autosomal recessive 31
Gene Ontology
HyperlinkGene Summary
In rat brain, Cip98 interacts with a calmodulin-dependent serine kinase, CASK (MIM 300172), and may be involved in the formation of scaffolding protein complexes that facilitate synaptic transmission in the central nervous system (CNS) (Yap et al., 2003 [PubMed 12641734]). Mutations in this gene, also known as WHRN, cause DFNB31 (MIM 607084).[supplied by OMIM
Other Designations
CASK-interacting protein CIP98|OTTHUMP00000021976|OTTHUMP00000021978|whirlin
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Interactome
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Disease
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