BACE2 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human BACE2 partial ORF ( NP_036237, 306 a.a. - 395 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
TTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYR
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.64
Interspecies Antigen Sequence
Mouse (88); Rat (88)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — BACE2
Entrez GeneID
25825GeneBank Accession#
NM_012105Protein Accession#
NP_036237Gene Name
BACE2
Gene Alias
AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Gene Description
beta-site APP-cleaving enzyme 2
Omim ID
605668Gene Ontology
HyperlinkGene Summary
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
56 kDa aspartic-like protease|Down syndrome region aspartic protease|aspartyl protease 1|beta secretase 2|beta-site amyloid beta A4 precursor protein-cleaving enzyme 2|memapsin-1|membrane-associated aspartic protease 1|transmembrane aspartic proteinase As
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Interactome
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Disease
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