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BACE2 rabbit monoclonal antibody

  • Catalog # : H00025825-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human BACE2 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human BACE2 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human BACE2 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • GeneBank Accession#:
  • BACE2
  • Gene Name:
  • BACE2
  • Gene Alias:
  • AEPLC,ALP56,ASP1,ASP21,BAE2,CDA13,CEAP1,DRAP
  • Gene Description:
  • beta-site APP-cleaving enzyme 2
  • Gene Summary:
  • Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
  • Other Designations:
  • 56 kDa aspartic-like protease,Down syndrome region aspartic protease,aspartyl protease 1,beta secretase 2,beta-site amyloid beta A4 precursor protein-cleaving enzyme 2,memapsin-1,membrane-associated aspartic protease 1,transmembrane aspartic proteinase As
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