GCA (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human GCA full-length ORF ( AAH05214, 1 a.a. - 217 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
49.61
Interspecies Antigen Sequence
Mouse (81); Rat (80)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — GCA
Entrez GeneID
25801GeneBank Accession#
BC005214Protein Accession#
AAH05214Gene Name
GCA
Gene Alias
GCL
Gene Description
grancalcin, EF-hand calcium binding protein
Omim ID
607030Gene Ontology
HyperlinkGene Summary
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq
Other Designations
grancalcin, EF-hand calcium-binding protein|grancalcin, penta-EF-hand protein
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Interactome
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Disease
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