RASGRP3 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
RASGRP3 transfected lysate.
Western Blot
Lane 1: RASGRP3 transfected lysate ( 76.01 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RASGRP3 full-length
Host
Human
Theoretical MW (kDa)
76.01
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RASGRP3 antibody (H00025780-B01) by Western Blots.
SDS-PAGE Gel
RASGRP3 transfected lysate.
Western Blot
Lane 1: RASGRP3 transfected lysate ( 76.01 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RASGRP3
Entrez GeneID
25780GeneBank Accession#
NM_170672Protein Accession#
NP_733772Gene Name
RASGRP3
Gene Alias
GRP3, KIAA0846
Gene Description
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Omim ID
609531Gene Ontology
HyperlinkGene Summary
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM
Other Designations
guanine nucleotide exchange factor for Rap1
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Interactome
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Pathway
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Disease
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