RASGRP3 MaxPab rabbit polyclonal antibody (D01)
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More Files
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Western Blot (Tissue lysate)
RASGRP3 MaxPab rabbit polyclonal antibody. Western Blot analysis of RASGRP3 expression in mouse kidney.
Western Blot (Transfected lysate)
Western Blot analysis of RASGRP3 expression in transfected 293T cell line (H00025780-T03) by RASGRP3 MaxPab polyclonal antibody.
Lane 1: RASGRP3 transfected lysate(78.3 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of RASGRP3 transfected lysate using anti-RASGRP3 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with RASGRP3 purified MaxPab mouse polyclonal antibody (B01P) (H00025780-B01P).
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to RASGRP3 on HeLa cell. [antibody concentration 30 ug/ml]
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human RASGRP3 protein.
Immunogen
RASGRP3 (NP_733772.1, 1 a.a. ~ 690 a.a) full-length human protein.
Sequence
MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
RASGRP3 MaxPab rabbit polyclonal antibody. Western Blot analysis of RASGRP3 expression in mouse kidney.Western Blot (Transfected lysate)
Western Blot analysis of RASGRP3 expression in transfected 293T cell line (H00025780-T03) by RASGRP3 MaxPab polyclonal antibody.
Lane 1: RASGRP3 transfected lysate(78.3 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of RASGRP3 transfected lysate using anti-RASGRP3 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with RASGRP3 purified MaxPab mouse polyclonal antibody (B01P) (H00025780-B01P).Immunofluorescence
Immunofluorescence of purified MaxPab antibody to RASGRP3 on HeLa cell. [antibody concentration 30 ug/ml] -
Gene Info — RASGRP3
Entrez GeneID
25780GeneBank Accession#
NM_170672.1Protein Accession#
NP_733772.1Gene Name
RASGRP3
Gene Alias
GRP3, KIAA0846
Gene Description
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Omim ID
609531Gene Ontology
HyperlinkGene Summary
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM
Other Designations
guanine nucleotide exchange factor for Rap1
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Interactome
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Pathway
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Disease
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