Western blot analysis of ZNF346 over-expressed 293 cell line, cotransfected with ZNF346 Validated Chimera RNAi ( Cat # H00023567-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with ZNF346 monoclonal antibody (M01), clone 2D10 (Cat # H00023567-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. [provided by RefSeq
double-stranded RNA-binding zinc finger protein JAZ