Immunoprecipitation of PRAME transfected lysate using anti-PRAME MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with PRAME purified MaxPab mouse polyclonal antibody (B01P) (H00023532-B01P).
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq
Opa-interacting protein OIP4,melanoma antigen preferentially expressed in tumors