Products

Western Blot (Transfected lysate)

Western Blot analysis of MACF1 expression in transfected 293T cell line by MACF1 monoclonal antibody (M08), clone 1G9.

Lane 1: MACF1 transfected lysate(10.45 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged MACF1 is 0.03 ng/ml as a capture antibody.

ELISA

Entrez GeneID

23499

GeneBank Accession#

BC007330

Protein Accession#

AAH07330

Gene Name

MACF1

Gene Alias

ABP620, ACF7, FLJ45612, FLJ46776, KIAA0465, KIAA1251, MACF, OFC4

Gene Description

microtubule-actin crosslinking factor 1

Omim ID

608271

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq

Other Designations

620 kDa actin binding protein|OTTHUMP00000009301|OTTHUMP00000009303|actin cross-linking factor|actin cross-linking family protein 7|macrophin 1|microfilament and actin filament cross-linker protein|trabeculin-alpha