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Last updated: 2016/12/4

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HAAO Pre-design Chimera RNAi

  • Catalog # : H00023498-R01
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  • Specification
  • Product Description:
  • Homo sapiens 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_012205
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Gene Name:
  • HAAO
  • Gene Alias:
  • 3-HAO,HAO
  • Gene Description:
  • 3-hydroxyanthranilate 3,4-dioxygenase
  • Gene Summary:
  • 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq
  • Other Designations:
  • 3-hydroxyanthranilate oxygenase,3-hydroxyanthranilic acid dioxygenase
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