HAAO monoclonal antibody (M05), clone 4D1
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More Files
- More Functions
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged HAAO is 0.1 ng/ml as a capture antibody.
Western Blot detection against Immunogen (36.63 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant HAAO.
Immunogen
HAAO (AAH29510.1, 97 a.a. ~ 196 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ANTVGLVVERRRLETELDGLRYYVGDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEPMSLDAWLDSHHRELQA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (85); Rat (87)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged HAAO is 0.1 ng/ml as a capture antibody.ELISA
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Gene Info — HAAO
Entrez GeneID
23498GeneBank Accession#
BC029510Protein Accession#
AAH29510.1Gene Name
HAAO
Gene Alias
3-HAO, HAO
Gene Description
3-hydroxyanthranilate 3,4-dioxygenase
Omim ID
604521Gene Ontology
HyperlinkGene Summary
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq
Other Designations
3-hydroxyanthranilate oxygenase|3-hydroxyanthranilic acid dioxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Advanced treatment of sewage by membrane bioreactor associate with genetically engineered autotrophic nitrifying bacteria.
Bai F, Tian H, Ma J.
Bioresource Technology 2019 Sep; 288:121341.
Application：WB-Ce, Bacterial, Wastewater.
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Advanced treatment of sewage by membrane bioreactor associate with genetically engineered autotrophic nitrifying bacteria.
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