QPRT (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human QPRT full-length ORF ( AAH05060.1, 1 a.a. - 297 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGILAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
58.3
Interspecies Antigen Sequence
Mouse (84); Rat (82)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — QPRT
Entrez GeneID
23475GeneBank Accession#
BC005060.1Protein Accession#
AAH05060.1Gene Name
QPRT
Gene Alias
QPRTase
Gene Description
quinolinate phosphoribosyltransferase
Omim ID
606248Gene Ontology
HyperlinkGene Summary
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq
Other Designations
nicotinate-nucleotide pyrophosphorylase (carboxylating)
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Interactome
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Pathway
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