COTL1 monoclonal antibody (M01), clone 1A2
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant COTL1.
Immunogen
COTL1 (AAH10884.1, 1 a.a. ~ 142 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MATKIDKEACRAAYNLVRDDGSAVIWVTFKYDGSTIVPGEQGAEYQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIKSELKKAGGANYDAQTE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (95)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (41.36 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of COTL1 expression in transfected 293T cell line by COTL1 monoclonal antibody (M01), clone 1A2.
Lane 1: COTL1 transfected lysate (Predicted MW: 15.9 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged COTL1 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — COTL1
Entrez GeneID
23406GeneBank Accession#
BC010884.1Protein Accession#
AAH10884.1Gene Name
COTL1
Gene Alias
CLP, FLJ43657, MGC19733
Gene Description
coactosin-like 1 (Dictyostelium)
Omim ID
606748Gene Ontology
HyperlinkGene Summary
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq
Other Designations
coactosin-like 1
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Interactome
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Disease
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