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NCSTN 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00023385-T02
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-NCSTN full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 76.7
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-NCSTN antibody (H00023385-D01P) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00023385-T02
    NCSTN transfected lysate.
    Western Blot
    QC Testing of H00023385-T02
    Lane 1: NCSTN transfected lysate ( 76.70 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • NCSTN
  • Gene Alias:
  • APH2,KIAA0253
  • Gene Description:
  • nicastrin
  • Gene Summary:
  • This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq
  • Other Designations:
  • ATAG1874,OTTHUMP00000031839,anterior pharynx-defective 2
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