NCSTN 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
NCSTN transfected lysate.
Western Blot
Lane 1: NCSTN transfected lysate ( 75.9 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-NCSTN full-length
Host
Human
Theoretical MW (kDa)
75.9
Interspecies Antigen Sequence
Mouse (88); Rat (88)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-NCSTN antibody (H00023385-B01) by Western Blots.
SDS-PAGE Gel
NCSTN transfected lysate.
Western Blot
Lane 1: NCSTN transfected lysate ( 75.9 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — NCSTN
Entrez GeneID
23385GeneBank Accession#
BC047621Protein Accession#
AAH47621Gene Name
NCSTN
Gene Alias
APH2, KIAA0253
Gene Description
nicastrin
Omim ID
605254Gene Ontology
HyperlinkGene Summary
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq
Other Designations
ATAG1874|OTTHUMP00000031839|anterior pharynx-defective 2
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Interactome
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