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Last updated: 2016/10/23
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NCSTN purified MaxPab rabbit polyclonal antibody (D01P)MaxPab

  • Catalog # : H00023385-D01P
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against a full-length human NCSTN protein.
  • Immunogen:
  • NCSTN (AAH47621.1, 1 a.a. ~ 689 a.a) full-length human protein.
  • Sequence:
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Quality Control Testing:
  • Antibody reactive against mammalian transfected lysate.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • NCSTN MaxPab rabbit polyclonal antibody. Western Blot analysis of NCSTN expression in mouse lung.
  • PDF DownloadProtocol Download
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of NCSTN expression in transfected 293T cell line (H00023385-T02) by NCSTN MaxPab polyclonal antibody.

    Lane 1: NCSTN transfected lysate(76.70 KDa).
    Lane 2: Non-transfected lysate.
  • PDF DownloadProtocol Download
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Gene Name:
  • Gene Alias:
  • APH2,KIAA0253
  • Gene Description:
  • nicastrin
  • Gene Summary:
  • This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq
  • Other Designations:
  • ATAG1874,OTTHUMP00000031839,anterior pharynx-defective 2
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