ARHGEF12 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human ARHGEF12 partial ORF ( NP_056128, 817 a.a. - 916 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
VSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Interspecies Antigen Sequence
Mouse (89); Rat (88)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ARHGEF12
Entrez GeneID
23365GeneBank Accession#
NM_015313Protein Accession#
NP_056128Gene Name
ARHGEF12
Gene Alias
DKFZp686O2372, KIAA0382, LARG, PRO2792
Gene Description
Rho guanine nucleotide exchange factor (GEF) 12
Gene Ontology
HyperlinkGene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia. [provided by RefSeq
Other Designations
leukemia-associated rho guanine nucleotide exchange factor
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Interactome
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Pathway
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Disease
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