ARHGEF12 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human ARHGEF12 peptide using ARM Technology.
Immunogen
A synthetic peptide of human ARHGEF12 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human ARHGEF12 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — ARHGEF12
Entrez GeneID
23365GeneBank Accession#
ARHGEF12Gene Name
ARHGEF12
Gene Alias
DKFZp686O2372, KIAA0382, LARG, PRO2792
Gene Description
Rho guanine nucleotide exchange factor (GEF) 12
Gene Ontology
HyperlinkGene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia. [provided by RefSeq
Other Designations
leukemia-associated rho guanine nucleotide exchange factor
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