SPG20 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human SPG20 peptide using ARM Technology.
Immunogen
A synthetic peptide of human SPG20 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human SPG20 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — SPG20
Entrez GeneID
23111GeneBank Accession#
SPG20Gene Name
SPG20
Gene Alias
KIAA0610, SPARTIN, TAHCCP1
Gene Description
spastic paraplegia 20 (Troyer syndrome)
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq
Other Designations
OTTHUMP00000018254|spartin|spastic paraplegia 20, spartin (Troyer syndrome)|spastic paraplegia autosomal recessive Troyer syndrome|trans-activated by hepatitis C virus core protein 1
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Interactome
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Disease
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