PEG10 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human PEG10 full-length ORF ( NP_001035242.1, 1 a.a. - 325 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MTERRRDELSEEINNLREKVMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAAAAAAPPPPIEEECPEDLPEKFDGNPDMLAPFMAQCQIFMEKSTRDFSVDRVRVCFVTSMMTGRAARWASAKLERSHYLMHNYPAFMMEMKHVFEDPQRREVAKRKIRRLRQGMGSVIDYSNAFQMIAQDLDWNEPALIDQYHEGLSDHIQEELSHLEVAKSLSALIGQCIHIERRLARAAAARKPRSPPRALVLPHIASHHQVDPTEPVGGARMRLTQEEKERRRKLNLCLYCGTGGHYADNCPAKASKSSPAGNSPAPL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
63.4
Interspecies Antigen Sequence
Mouse (65)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PEG10
Entrez GeneID
23089GeneBank Accession#
NM_001040152.1Protein Accession#
NP_001035242.1Gene Name
PEG10
Gene Alias
Edr, HB-1, KIAA1051, MEF3L, Mar2, Mart2, RGAG3
Gene Description
paternally expressed 10
Omim ID
609810Gene Ontology
HyperlinkGene Summary
This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas. [provided by RefSeq
Other Designations
MEF3 like 1|embryonal carcinoma differentiation regulated|retrotransposon gag domain containing 3
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