NMNAT2 monoclonal antibody (M04), clone 2G8
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant NMNAT2.
Immunogen
NMNAT2 (AAH20998, 1 a.a. ~ 302 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MEIQELEEIQACQGLWEVFVTLSERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQLYINASG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged NMNAT2 is 3 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to NMNAT2 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — NMNAT2
Entrez GeneID
23057GeneBank Accession#
BC020998Protein Accession#
AAH20998Gene Name
NMNAT2
Gene Alias
C1orf15, KIAA0479, MGC2756, PNAT-2, PNAT2
Gene Description
nicotinamide nucleotide adenylyltransferase 2
Omim ID
608701Gene Ontology
HyperlinkGene Summary
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000033548|OTTHUMP00000033549|nicotinamide mononucleotide adenylyltransferase 2|pyridine nucleotide adenylyltransferase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD + and ATP.
Tingpeng Yang, Yanzhi Wang, Weijie Liao, Shikuan Zhang, Songmao Wang, Naihan Xu, Weidong Xie, Cheng Luo, Yangyang Wang, Ziqiang Wang, Yaou Zhang.
Cell & Bioscience 2021 Nov; 11(1):192.
Application:WB-Ce, Human, SH-SY5Y, U251 cells.
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Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons.
Ali YO, Bradley G, Lu HC.
Scientific Reports 2017 Mar; 7:43846.
Application:WB, Mouse, Mouse DIV14 cortical neurons.
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Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD + and ATP.
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