SHANK2 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human SHANK2 partial ORF ( NP_036441, 1034 a.a. - 1124 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.75
Interspecies Antigen Sequence
Rat (88)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SHANK2
Entrez GeneID
22941GeneBank Accession#
NM_012309Protein Accession#
NP_036441Gene Name
SHANK2
Gene Alias
CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3
Gene Description
SH3 and multiple ankyrin repeat domains 2
Omim ID
603290Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq
Other Designations
GKAP/SAPAP interacting protein|cortactin SH3 domain-binding protein|cortactin binding protein 1
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Interactome
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Disease
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