CARD8 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
CARD8 transfected lysate.
Western Blot
Lane 1: CARD8 transfected lysate ( 44 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CARD8 full-length
Host
Human
Theoretical MW (kDa)
43.23
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CARD8 antibody (H00022900-B01) by Western Blots.
SDS-PAGE Gel
CARD8 transfected lysate.
Western Blot
Lane 1: CARD8 transfected lysate ( 44 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CARD8
Entrez GeneID
22900GeneBank Accession#
BC056891Protein Accession#
AAH56891Gene Name
CARD8
Gene Alias
CARDINAL, DACAR, DKFZp779L0366, Dakar, FLJ18119, FLJ18121, KIAA0955, MGC57162, NDPP, NDPP1, TUCAN
Gene Description
caspase recruitment domain family, member 8
Omim ID
609051Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CARD inhibitor of NF-kappaB-activating ligands|CARD8 isoform T47|CARD8 isoform T51|CARD8 isoform T60|apoptotic protein NDPP1|tumor up-regulated CARD-containing antagonist of caspase nine
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Interactome
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Disease
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