Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

CARD8

Gene Alias

CARDINAL, DACAR, DKFZp779L0366, Dakar, FLJ18119, FLJ18121, KIAA0955, MGC57162, NDPP, NDPP1, TUCAN

Gene Description

caspase recruitment domain family, member 8

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq

Other Designations

CARD inhibitor of NF-kappaB-activating ligands|CARD8 isoform T47|CARD8 isoform T51|CARD8 isoform T60|apoptotic protein NDPP1|tumor up-regulated CARD-containing antagonist of caspase nine