CARD8 MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of CARD8 expression in transfected 293T cell line (H00022900-T02) by CARD8 MaxPab polyclonal antibody.
Lane 1: CARD8 transfected lysate(44 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of CARD8 transfected lysate using anti-CARD8 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with CARD8 purified MaxPab mouse polyclonal antibody (B01P) (H00022900-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human CARD8 protein.
Immunogen
CARD8 (AAH56891.1, 1 a.a. ~ 392 a.a) full-length human protein.
Sequence
MEKKECPEKSSSSEEELPRRDSGSSRNIDASKLIRLQGSRKLLVDNSIRELQYTKTGIFFQAEACVTNDTVYRELPCVSETLCDISHFFQEDDETEAEPLLFRAVPECQLSGGDIPSVSEEQESSEGQDSGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHSISLQAGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKWISSL
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CARD8 expression in transfected 293T cell line (H00022900-T02) by CARD8 MaxPab polyclonal antibody.
Lane 1: CARD8 transfected lysate(44 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of CARD8 transfected lysate using anti-CARD8 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with CARD8 purified MaxPab mouse polyclonal antibody (B01P) (H00022900-B01P). -
Gene Info — CARD8
Entrez GeneID
22900GeneBank Accession#
BC056891Protein Accession#
AAH56891.1Gene Name
CARD8
Gene Alias
CARDINAL, DACAR, DKFZp779L0366, Dakar, FLJ18119, FLJ18121, KIAA0955, MGC57162, NDPP, NDPP1, TUCAN
Gene Description
caspase recruitment domain family, member 8
Omim ID
609051Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CARD inhibitor of NF-kappaB-activating ligands|CARD8 isoform T47|CARD8 isoform T51|CARD8 isoform T60|apoptotic protein NDPP1|tumor up-regulated CARD-containing antagonist of caspase nine
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Interactome
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Disease
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