This antibody pair set comes with matched antibody pair to detect and quantify protein level of human CARD8.
Quality Control Testing:
Standard curve using recombinant protein ( H00022900-P01 ) as an analyte.
Sandwich ELISA detection sensitivity ranging from 1 ng/ml to 100 ng/ml.
Antibody pair set content: 1. Capture antibody: rabbit MaxPab® affinity purified polyclonal anti-CARD8 (100 ug) 2. Detection antibody: mouse purified polyclonal anti-CARD8 (20 ug) *Reagents are sufficient for at least 1-2 x 96 well plates using recommended protocols.
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq
CARD inhibitor of NF-kappaB-activating ligands,CARD8 isoform T47,CARD8 isoform T51,CARD8 isoform T60,apoptotic protein NDPP1,tumor up-regulated CARD-containing antagonist of caspase nine