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PUF60 rabbit monoclonal antibody

  • Catalog # : H00022827-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human PUF60 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human PUF60 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human PUF60 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • Application Image
  • Western Blot (Transfected lysate)
  • Gene Information
  • GeneBank Accession#:
  • PUF60
  • Gene Name:
  • PUF60
  • Gene Alias:
  • Gene Description:
  • poly-U binding splicing factor 60KDa
  • Gene Summary:
  • The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene. [provided by RefSeq
  • Other Designations:
  • FBP interacting repressor,Ro ribonucleoprotein binding protein 1,Ro ribonucleoprotein-binding protein 1,fuse-binding protein-interacting repressor,poly-U binding splicing factor PUF60,pyrimidine tract binding splicing factor,siah binding protein 1
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