Western blot analysis of COG2 over-expressed 293 cell line, cotransfected with COG2 Validated Chimera RNAi ( Cat # H00022796-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with COG2 monoclonal antibody (M09), clone 4C8 (Cat # H00022796-M09 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants
OTTHUMP00000035875,brefeldin A-sensitive, peripheral Golgi protein,conserved oligomeric Golgi complex protein 2,low density lipoprotein receptor defect C complementing,transcript ch4822