B4GALT7 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-B4GALT7 full-length
Host
Human
Theoretical MW (kDa)
36.08
Interspecies Antigen Sequence
Mouse (92); Rat (92)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-B4GALT7 antibody (H00011285-B01) by Western Blots.
SDS-PAGE Gel
B4GALT7 transfected lysate.
Western Blot
Lane 1: B4GALT7 transfected lysate ( 36.08 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — B4GALT7
Entrez GeneID
11285GeneBank Accession#
NM_007255.1Protein Accession#
NP_009186.1Gene Name
B4GALT7
Gene Alias
B4GAL-T7, XGALT-1, XGALT1, XGPT1, beta4Gal-T7
Gene Description
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
Gene Ontology
HyperlinkGene Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) linkage found in proteoglycans. Manganese is required as a cofactor. This enzyme differs from the other six beta4GalTs because it lacks the conserved beta4GalT1-beta4GalT6 Cys residues and it is located in cis-Golgi instead of trans-Golgi. Two single-nucleotide mutations were identified from a patient with the progeroid type of Ehlers-Danlos syndrome. [provided by RefSeq
Other Designations
beta-1,4-galactosyltransferase 7|galactosyltransferase 1 (xylosylprotein 4-beta-galactosyltransferase)|xylosylprotein beta 1,4-galactosyltransferase 7
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Interactome
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Pathway
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