Products

Western Blot (Cell lysate)

B4GALT7 MaxPab polyclonal antibody. Western Blot analysis of B4GALT7 expression in HepG2.

Western Blot (Transfected lysate)

Western Blot analysis of B4GALT7 expression in transfected 293T cell line (H00011285-T01) by B4GALT7 MaxPab polyclonal antibody.

Lane 1: B4GALT7 transfected lysate(35.97 KDa).
Lane 2: Non-transfected lysate.

Entrez GeneID

11285

GeneBank Accession#

NM_007255.1

Protein Accession#

NP_009186.1

Gene Name

B4GALT7

Gene Alias

B4GAL-T7, XGALT-1, XGALT1, XGPT1, beta4Gal-T7

Gene Description

xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)

Omim ID

130070 604327

Gene Ontology

Hyperlink

Gene Summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) linkage found in proteoglycans. Manganese is required as a cofactor. This enzyme differs from the other six beta4GalTs because it lacks the conserved beta4GalT1-beta4GalT6 Cys residues and it is located in cis-Golgi instead of trans-Golgi. Two single-nucleotide mutations were identified from a patient with the progeroid type of Ehlers-Danlos syndrome. [provided by RefSeq

Other Designations

beta-1,4-galactosyltransferase 7|galactosyltransferase 1 (xylosylprotein 4-beta-galactosyltransferase)|xylosylprotein beta 1,4-galactosyltransferase 7