TREX1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
Western Blot
Lane 1: TREX1 transfected lysate ( 38.9 KDa)
Lane 2: Non-transfected lysate.
SDS-PAGE Gel
TREX1 transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-TREX1 full-length
Host
Human
Theoretical MW (kDa)
40.7
Interspecies Antigen Sequence
Mouse (73); Rat (74)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-TREX1 antibody (H00011277-B02) by Western Blots.
Western Blot
Lane 1: TREX1 transfected lysate ( 38.9 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
TREX1 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — TREX1
Entrez GeneID
11277GeneBank Accession#
NM_016381Protein Accession#
NP_057465Gene Name
TREX1
Gene Alias
AGS1, AGS5, CRV, DKFZp434J0310, DRN3, HERNS
Gene Description
three prime repair exonuclease 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
3' repair exonuclease 1|OTTHUMP00000164813|deoxyribonuclease III, dnaQ/mutD-like
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Interactome
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Disease
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