POLG2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human POLG2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human POLG2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human POLG2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — POLG2
Entrez GeneID
11232GeneBank Accession#
POLG2Gene Name
POLG2
Gene Alias
HP55, MTPOLB, PEOA4, POLB, POLG-BETA, POLGB
Gene Description
polymerase (DNA directed), gamma 2, accessory subunit
Gene Ontology
HyperlinkGene Summary
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions
Other Designations
mitochondrial DNA polymerase, accessory subunit
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Interactome
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