RASSF1 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RASSF1 full-length
Host
Human
Theoretical MW (kDa)
29.81
Interspecies Antigen Sequence
Mouse (92); Rat (91)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RASSF1 antibody (H00011186-B01) by Western Blots.
Western Blot
Lane 1: RASSF1 transfected lysate ( 29.7 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
RASSF1 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RASSF1
Entrez GeneID
11186GeneBank Accession#
NM_007182Protein Accession#
NP_009113Gene Name
RASSF1
Gene Alias
123F2, NORE2A, RASSF1A, RDA32, REH3P21
Gene Description
Ras association (RalGDS/AF-6) domain family member 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000195503|Ras association (RalGDS/AF-6) domain family 1|Ras association domain family 1|Ras association domain family protein 1|WUGSC:H_LUCA12.5|cardiac-specific ras association domain family 1 protein|pancreas-specific ras association domain fam
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Interactome
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Pathway
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Disease
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