ZWINT (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human ZWINT full-length ORF ( AAH20979, 1 a.a. - 277 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MEAAETEAEAAALEVLAEVAGILEPVGLQEEAELPAKILVEFVVDSQKKDKLLCSQLQVADFLQNILAQEDTAKGLDPLASEDTSRQKAIAAKEQWKELKATYREHVEAIKIGLTKALTQMEEAQRKRTQLREAFEQLQAKKQMAMEKRRAVQNQWQLQQEKHLQHLAEVSAEVRERKTGTQQELDGVFQKLGNLKQQAEQERDKLQRYQTFLQLLYTLQGKLLFPEAEAEAENLPDDKPQQPTRPQEQSTGDTMGRDPGVSFKAVGLQPAGDVNLP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
56.21
Interspecies Antigen Sequence
Mouse (59); Rat (58)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ZWINT
Entrez GeneID
11130GeneBank Accession#
BC020979Protein Accession#
AAH20979Gene Name
ZWINT
Gene Alias
HZwint-1, KNTC2AP, MGC117174, ZWINT1
Gene Description
ZW10 interactor
Omim ID
609177Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000019626|OTTHUMP00000019628|human ZW10 interacting protein-1
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Interactome
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Disease
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Publication Reference
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Beclin-1 is required for chromosome congression and proper outer kinetochore assembly.
Fremont S, Gerard A, Galloux M, Janvier K, Karess RE, Berlioz-Torrent C.
EMBO Reports 2013 Apr; 14(4):364.
Application：Func, IP, WB-Re, Recombinant protein.
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Beclin-1 is required for chromosome congression and proper outer kinetochore assembly.
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