ZWINT purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against a full-length human ZWINT protein.
Immunogen
ZWINT (AAH20979.1, 1 a.a. ~ 277 a.a) full-length human protein.
Sequence
MEAAETEAEAAALEVLAEVAGILEPVGLQEEAELPAKILVEFVVDSQKKDKLLCSQLQVADFLQNILAQEDTAKGLDPLASEDTSRQKAIAAKEQWKELKATYREHVEAIKIGLTKALTQMEEAQRKRTQLREAFEQLQAKKQMAMEKRRAVQNQWQLQQEKHLQHLAEVSAEVRERKTGTQQELDGVFQKLGNLKQQAEQERDKLQRYQTFLQLLYTLQGKLLFPEAEAEAENLPDDKPQQPTRPQEQSTGDTMGRDPGVSFKAVGLQPAGDVNLP
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (59); Rat (58)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of ZWINT expression in transfected 293T cell line (H00011130-T02) by ZWINT MaxPab polyclonal antibody.
Lane 1: ZWINT transfected lysate(31.20 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — ZWINT
Entrez GeneID
11130GeneBank Accession#
BC020979.1Protein Accession#
AAH20979.1Gene Name
ZWINT
Gene Alias
HZwint-1, KNTC2AP, MGC117174, ZWINT1
Gene Description
ZW10 interactor
Omim ID
609177Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000019626|OTTHUMP00000019628|human ZW10 interacting protein-1
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Interactomes
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Diseases
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Publication Reference
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A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.
Matson DR, Demirel PB, Stukenberg PT, Burke DJ.
Genes & Development 2012 Mar; 26(6):542.
Application:IF, Human, HeLa cells.
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A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.
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