KATNA1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human KATNA1 full-length ORF ( AAH50428.1, 1 a.a. - 311 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSGMRP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
61.7
Interspecies Antigen Sequence
Mouse (61); Rat (84)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — KATNA1
Entrez GeneID
11104GeneBank Accession#
BC050428.1Protein Accession#
AAH50428.1Gene Name
KATNA1
Gene Alias
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Gene Description
katanin p60 (ATPase-containing) subunit A 1
Omim ID
606696Gene Ontology
HyperlinkGene Summary
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. [provided by RefSeq
Other Designations
OTTHUMP00000017392|katanin p60 subunit A 1
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Interactome
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Publication Reference
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Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y.
European Journal of Medicinal Chemistry 2019 Sep; 178:177.
Application：Func, Compound.
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Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
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