DUSP14 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
DUSP14 transfected lysate.
Western Blot
Lane 1: DUSP14 transfected lysate ( 21.89 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-DUSP14 full-length
Host
Human
Theoretical MW (kDa)
21.89
Interspecies Antigen Sequence
Mouse (93); Rat (94)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-DUSP14 antibody (H00011072-B01) by Western Blots.
SDS-PAGE Gel
DUSP14 transfected lysate.
Western Blot
Lane 1: DUSP14 transfected lysate ( 21.89 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — DUSP14
Entrez GeneID
11072GeneBank Accession#
NM_007026.1Protein Accession#
-Gene Name
DUSP14
Gene Alias
MKP-L, MKP6
Gene Description
dual specificity phosphatase 14
Omim ID
606618Gene Ontology
HyperlinkGene Summary
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM
Other Designations
MKP-1 like protein tyrosine phosphatase|OTTHUMP00000164064|OTTHUMP00000164065
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Interactome
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Pathway
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