LECT1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-LECT1 full-length
Host
Human
Theoretical MW (kDa)
36.85
Interspecies Antigen Sequence
Mouse (88); Rat (88)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-LECT1 antibody (H00011061-B01) by Western Blots.
SDS-PAGE Gel
LECT1 transfected lysate.
Western Blot
Lane 1: LECT1 transfected lysate ( 36.85 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — LECT1
Entrez GeneID
11061GeneBank Accession#
NM_007015.2Protein Accession#
NP_008946.1Gene Name
LECT1
Gene Alias
BRICD3, CHM-I, CHM1
Gene Description
leukocyte cell derived chemotaxin 1
Omim ID
605147Gene Ontology
HyperlinkGene Summary
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
BRICHOS domain containing 3|OTTHUMP00000018466|chondromodulin I
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