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KDELR2 (Human) Recombinant Protein (P01)

  • Catalog # : H00011014-P01
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  • Specification
  • Product Description:
  • Human KDELR2 full-length ORF ( NP_006845.1, 1 a.a. - 212 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 50.8
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00011014-P01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Gene Name:
  • KDELR2
  • Gene Alias:
  • ELP-1,ERD2.2,FLJ45532
  • Gene Description:
  • KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
  • Gene Summary:
  • Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
  • Other Designations:
  • (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2,ERD-2-like protein,KDEL receptor 2
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