EDAR monoclonal antibody (M01), clone 6C12
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant EDAR.
Immunogen
EDAR (NP_071731, 64 a.a. ~ 178 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
TKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKEL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (85); Rat (84)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.39 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
EDAR monoclonal antibody (M01), clone 6C12. Western Blot analysis of EDAR expression in human kidney.Western Blot (Recombinant protein)
ELISA
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Gene Info — EDAR
Entrez GeneID
10913GeneBank Accession#
NM_022336Protein Accession#
NP_071731Gene Name
EDAR
Gene Alias
DL, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, FLJ94390
Gene Description
ectodysplasin A receptor
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq
Other Designations
downless, mouse, homolog of|ectodysplasin 1, anhidrotic receptor
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Interactome
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Pathway
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Disease
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