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Last updated: 2016/12/4

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PPARGC1A rabbit monoclonal antibody

  • Catalog # : H00010891-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human PPARGC1A peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human PPARGC1A is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human PPARGC1A peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Gene Name:
  • PPARGC1A
  • Gene Alias:
  • LEM6,PGC-1(alpha),PGC-1v,PGC1,PGC1A,PPARGC1
  • Gene Description:
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
  • Gene Summary:
  • The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000123372,PPAR gamma coactivator variant form,PPAR gamma coactivator-1,ligand effect modulator-6,peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
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