FRS2 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human FRS2 partial ORF ( AAH21562.1, 1 a.a. - 341 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMSQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQ
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
63.14
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — FRS2
Entrez GeneID
10818GeneBank Accession#
BC021562Protein Accession#
AAH21562.1Gene Name
FRS2
Gene Alias
FRS2A, FRS2alpha, SNT, SNT-1, SNT1
Gene Description
fibroblast growth factor receptor substrate 2
Omim ID
607743Gene Ontology
HyperlinkOther Designations
FGFR signalling adaptor|suc1-associated neurotrophic factor target
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Interactome
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Pathway
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Disease
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Publication Reference
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STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes.
Krejci P, Salazar L, Goodridge HS, Kashiwada TA, Schibler MJ, Jelinkova P, Thompson LM, Wilcox WR.
Journal of Cell Science 2008 Jan; 121(Pt 3):272.
Application：KA, Recombinant protein.
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Bisindolylmaleimide I suppresses FGF-mediated activation of ERK map kinase in chondrocytes by preventing SHP2 association with the FRS2 and GAB1 adaptor proteins.
Krejci P, Masri B, Salazar L, Farrington-Rock C, Prats H, Thompson LM, Wilcox WR.
The Journal of Biological Chemistry 2006 Dec; 282(5):2929.
Application：KA, IP, Rat, RCS cells.
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STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes.
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