IGF2BP2 monoclonal antibody (M01), clone 4C6
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More Files
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Western Blot (Cell lysate)
IGF2BP2 monoclonal antibody (M01), clone 4C6. Western Blot analysis of IGF2BP2 expression in K-562(Cat # L009V1 ).
Western Blot (Transfected lysate)
Western Blot analysis of IGF2BP2 expression in transfected 293T cell line by IGF2BP2 monoclonal antibody (M01), clone 4C6.
Lane 1: IGF2BP2 transfected lysate (Predicted MW: 66 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of IGF2BP2 transfected lysate using anti-IGF2BP2 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with IGF2BP2 monoclonal antibody.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged IGF2BP2 is 1 ng/ml as a capture antibody.
Western Blot detection against Immunogen (91.52 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant IGF2BP2.
Immunogen
IGF2BP2 (AAH21290, 1 a.a. ~ 598 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (91.52 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
IGF2BP2 monoclonal antibody (M01), clone 4C6. Western Blot analysis of IGF2BP2 expression in K-562(Cat # L009V1 ).Western Blot (Transfected lysate)
Western Blot analysis of IGF2BP2 expression in transfected 293T cell line by IGF2BP2 monoclonal antibody (M01), clone 4C6.
Lane 1: IGF2BP2 transfected lysate (Predicted MW: 66 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Immunoprecipitation
Immunoprecipitation of IGF2BP2 transfected lysate using anti-IGF2BP2 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with IGF2BP2 monoclonal antibody.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged IGF2BP2 is 1 ng/ml as a capture antibody.ELISA
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Gene Info — IGF2BP2
Entrez GeneID
10644GeneBank Accession#
BC021290Protein Accession#
AAH21290Gene Name
IGF2BP2
Gene Alias
IMP-2, IMP2, VICKZ2, p62
Gene Description
insulin-like growth factor 2 mRNA binding protein 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
IGF II mRNA binding protein 2|IGF-II mRNA-binding protein 2|insulin-like 2 growth factor 2-binding protein 2
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Interactome
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Disease
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Publication Reference
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The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition.
Oliveira-Mateos C, Sánchez-Castillo A, Soler M, Obiols-Guardia A, Piñeyro D, Boque-Sastre R, Calleja-Cervantes ME, Castro de Moura M, Martínez-Cardús A, Rubio T, Pelletier J, Martínez-Iniesta M, Herrero-Martín D, Tirado OM, Gentilella A, Villanueva A, Esteller M, Farré L, Guil S.
Nature Communications 2019 Sep; 10(1):3979.
Application：Dot, IP, WB, Human, A673 cells.
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The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition.
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