IGF2BP1 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human IGF2BP1 full-length ORF (AAI52771.1, 1 a.a. - 577 a.a.) recombinant protein with GST tag at N-terminal.
Sequence
MNKLYIGNLNESVTPADLEKVFAEHKISYSGQFLVKSGYAFVDCPDEHWAMKAIETFSGKVELQGKRLEIEHSVPKKQRSRKIQIRNIPPQLRWEVLDSLLAQYGTVENCEQVNTESETAVVNVTYSNREQTRQAIMKLNGHQLENHALKVSYIPDEQIAQGPENGRRGGFGSRGQPRQGSPVAAGAPAKQQQVDIPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKAISVHSTPEGCSSACKMILEIMHKEAKDTKTADEVPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQDLTLYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLIPGLNLAAVGLFPASSSAVPPPPSSVTGAAPYSSFMQAPEQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIKIAPPETPDSKVRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIRVPASAAGRVIGKGGKTVNELQNLTAAEVVVPRDQTPDENDQVIVKIIGHFYASQMAQRKIRDILAQVKQQHQKGQSNQAQARRK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
89.87
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — IGF2BP1
Entrez GeneID
10642GeneBank Accession#
BC152770.1Protein Accession#
AAI52771.1Gene Name
IGF2BP1
Gene Alias
CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1
Gene Description
insulin-like growth factor 2 mRNA binding protein 1
Omim ID
608288Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
IGF II mRNA binding protein 1|IGF-II mRNA-binding protein 1|coding region determinant-binding protein
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Interactome
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Disease
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Publication Reference
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APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly.
Qiang Wang, Chen Chen, Xiao Xu, Chuanjun Shu, Changchang Cao, Zhangding Wang, Yao Fu, Lei Xu, Kaiyue Xu, Jiawen Xu, Anliang Xia, Bo Wang, Guifang Xu, Xiaoping Zou, Ruibao Su, Wei Kang, Yuanchao Xue, Ran Mo, Beicheng Sun, Shouyu Wang.
Advanced Science (Weinheim, Baden-Württemberg, Germany) 2022 Aug; e2201889.
Application：Pull-Down, Human, BGC823 cell.
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Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome.
Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T.
Human Molecular Genetics 2014 Dec; 23(23):6177.
Application：IF, WB-Ti, Mouse, Brain.
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APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly.
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